Signal the body to heal faster.

01 / Bone Growth Stimulation

Signal the body to heal faster.

A continuously wearable bone growth stimulation system built to fit into a patient's day rather than interrupt it, compact enough to clip on a belt or tuck into a pocket, with no restricted postures and no scheduled sessions. Built-in sensors and a proprietary algorithm track wear time and relative activity level automatically, combined with patient-reported pain scores in a companion app for a clear day-to-day view of recovery. Clinicians get that same picture through a remote portal that flags patients whose progress may be falling off track. Preclinical data also shows increasing bone cell proliferation the longer the device is worn each day, consistent with a dose-dependent response.

The mechanism is well characterized. Work by Brighton and colleagues established that capacitively coupled signal transduction in bone cells proceeds through voltage-gated calcium channels — proliferation is blocked by verapamil, a calcium channel blocker, but not by inositol-phosphate inhibitors, which distinguishes it from the inductive-coupling pathway. The resulting rise in cytosolic calcium activates calmodulin and upregulates TGF-β1 and other osteopromotive factors.

The clinical evidence supports the modality independently of any one device. A Level I systematic review and meta-analysis of randomized controlled trials (n=941) found postoperative electrical stimulation increased the odds of successful fusion 2.5-fold relative to control, with no significant subgroup interaction by stimulation type. In a randomized, double-blind, placebo-controlled trial of capacitively coupled stimulation across 28 U.S. surgical sites, 84.7% of actively stimulated patients met the combined clinical and radiographic success criteria versus 64.9% on placebo.

Mechanism: capacitively coupled stimulation of osteogenesis · wear-time linked dosing · Level I evidence for the modality